Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
Identifieur interne : 002058 ( Main/Exploration ); précédent : 002057; suivant : 002059Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
Auteurs : Nadeeka N. W. Dissanayaka [Australie] ; Peter A. Silburn [Australie] ; John D. O'Sullivan [Australie] ; George D. Mellick [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-01-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Alleles, Depression, Depression (diagnosis), Depression (epidemiology), Depression (etiology), Depression (genetics), Depression (metabolism), Dopamine, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (physiology), European Continental Ancestry Group (genetics), Genetic variant, Genotype, Haplotype, Haplotypes (genetics), Humans, Linkage Disequilibrium, Minisatellite Repeats, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Polymorphism, Single Nucleotide, Queensland (epidemiology), Questionnaires, SLC6A3, SLC6A4, Serotonin (metabolism), Serotonin Plasma Membrane Transport Proteins (genetics), Serotonin Plasma Membrane Transport Proteins (physiology), Serotonin transporter, depression, genetic variants, haplotypes.
- MESH :
- chemical , genetics : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- chemical , metabolism : Dopamine, Serotonin.
- geographic , epidemiology : Queensland.
- complications : Parkinson Disease.
- diagnosis : Depression.
- epidemiology : Depression, Parkinson Disease.
- etiology : Depression.
- genetics : Depression, European Continental Ancestry Group, Haplotypes, Parkinson Disease.
- metabolism : Depression, Parkinson Disease.
- chemical , physiology : Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins.
- psychology : Parkinson Disease.
- Alleles, Genotype, Humans, Linkage Disequilibrium, Minisatellite Repeats, Polymorphism, Single Nucleotide, Questionnaires.
Abstract
Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22134
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-01-15">2009-01-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="111">111</biblScope><biblScope unit="page" to="115">115</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">756C147B873B3C6304D7C96A9216C0996635C439</idno><idno type="DOI">10.1002/mds.22134</idno><idno type="ArticleID">MDS22134</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Depression</term><term>Depression (diagnosis)</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Depression (genetics)</term><term>Depression (metabolism)</term><term>Dopamine</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (genetics)</term><term>Dopamine Plasma Membrane Transport Proteins (physiology)</term><term>European Continental Ancestry Group (genetics)</term><term>Genetic variant</term><term>Genotype</term><term>Haplotype</term><term>Haplotypes (genetics)</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (psychology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Polymorphism, Single Nucleotide</term><term>Queensland (epidemiology)</term><term>Questionnaires</term><term>SLC6A3</term><term>SLC6A4</term><term>Serotonin (metabolism)</term><term>Serotonin Plasma Membrane Transport Proteins (genetics)</term><term>Serotonin Plasma Membrane Transport Proteins (physiology)</term><term>Serotonin transporter</term><term>depression</term><term>genetic variants</term><term>haplotypes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Serotonin</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Queensland</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>European Continental Ancestry Group</term><term>Haplotypes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Minisatellite Repeats</term><term>Polymorphism, Single Nucleotide</term><term>Questionnaires</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Etat dépressif</term><term>Haplotype</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Transporteur sérotonine</term><term>Variant génétique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log‐additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N. W." last="Dissanayaka">Nadeeka N. W. Dissanayaka</name></noRegion><name sortKey="Dissanayaka, Nadeeka N W" sort="Dissanayaka, Nadeeka N W" uniqKey="Dissanayaka N" first="Nadeeka N. W." last="Dissanayaka">Nadeeka N. W. Dissanayaka</name><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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